Dr Mehta is a global leader in retinal research.

He is a Senior Researcher with Save Sight Registries, University of Sydney, aiming to improve outcomes of currently available intravitreal injection therapies. His research at Sydney Eye Hospital and Moorfields Eye Hospital contributed to his Doctorate of Medicine on “Novel endpoints in diabetic retinopathy clinical trials” registered at Cambridge University. He offers clinical trials of new therapies for macula disease.

Clinical trials

Hemal Mehta has been involved in designing and conducting clinical trials of new longer lasting intravitreal injection therapies for macula disease that will soon be available to the public. He is happy to discuss and advise on your suitability for the latest clinical trials of treatments for wet age-related macular degeneration, dry age-related macular degeneration, diabetic retinopathy and retinal vein occlusions.

He previously led the clinical trials unit at the Royal Free London NHS Foundation Trust, recruiting the first patient in Europe to the PANOPTICA study, the first eyedrop for wet age-related macular degeneration to show promise in early phase clinical trials. He was involved in the seminal investigator-initiated BEVORDEX clinical trial at Sydney Eye Hospital and analysis of this unique dataset contributed to his higher research degree titled “Novel endpoints in diabetic retinopathy clinical trials”.  

Optimising intravitreal injection outcomes

Dr Mehta is a senior researcher with Save Sight Registries, University of Sydney. He is on the Steering Committee of the Fight Retinal Blindness! (FRB!) registry. The FRB! registry enables clinicians to track outcomes of interventions such as intravitreal therapy for age-related macular degeneration and diabetic retinopathy. By analysing this anonymised big data, we can better understand how to optimise treatments to improve patient outcomes.

Building on the success of the FRB! registry in Australia, the use of this audit tool is now expanding globally. Dr Mehta is facilitating this international collaboration through his roles as an advisor for the Royal College of Ophthalmologists national age-related macular degeneration audit, Honorary Ophthalmology Consultant at the Royal Free London NHS Foundation Trust, and the primary ophthalmology clinical advisor for Fast Healthcare Interoperability Resources (FHIR®).

Publications

  • Hedayat Javidi, Sarah Ah-Moye, Charles Hennings, Hemal Mehta, Sajjad Mahmood. Presumed Sertraline-Associated Maculopathy: A Case Series. Ophthalmology and Therapy. 2021 Jun;10(2):359-365. DOI:10.1007/s40123-021-00340-7.

    Lesions at the back of the eye
  • Konstantinos Balaskas, Winfried M. Amoaku, Tomas Cudrnak, Louise M. Downey, Markus Groppe, Sajjad Mahmood, Hemal Mehta, Quresh Mohamed, Bushra Mushtaq, Philip Severn, Athanasios Vardarinos, Yit C. Yang. Importance of anatomical efficacy for disease control in neovascular AMD: An expert opinion. Ophthalmology and Therapy. 2021 Jun;10(2):231-243. DOI: 10.1007/s40123-021-00342-5.

    Age-related macular degeneration
  • Wedad S. Salem, Sophia L. Zagora, Vuong Nguyen, Hemal Mehta, Mark C. Gillies, Samantha Fraserā€Bell. Effect of intravitreal injection speed on acute rise in intraocular pressure. The SPEED IOP study. Clinical and Experimental Ophthalmology. April 2021. DOI:10.1111/ceo.13934

    Age-related macular degeneration
  • Adrian Hunt, Vuong Nguyen, Catherine Creuzot-Garcher, Socorro Alforja, Pierre-Henry Gabrielle, Javier Zarranz-Ventura, Martin Guillemin, Samantha Fraser-Bell, Ricardo P. Casaroli-Marano, Jennifer Arnold, Ian McAllister, Louise O' Toole, Mark C. Gillies, Daniel Barthelmes, Hemal Mehta. Twelve-month outcomes of ranibizumab versus aflibercept for macular oedema in branch retinal vein occlusion: data from the Fight Retinal Blindness! registry. The British Journal of Ophthalmology. 2021 Mar 12: DOI:10.1136/bjophthalmol-2020-318491

    Retinal vein occlusion
  • Rawan Ahmad, Hemal Mehta. The ocular adverse effects of oral drugs. Australian Prescriber. 2021. In press.

    Lesions at the back of the eye
  • Hemal Mehta. Management of cataract in patients with age-related macular degeneration. Journal of Clinical Medicine. 2021, 10, 2538. DOI:10.3390/jcm10122538

    Cataract surgery
  • Hemal Mehta & Senthil Selvam. Book chapter on “Intravitreal injection therapies”. Editors: Parham Azabod and Professor Sir Peng Tee Khaw. Key Clinical Topics in Ophthalmology. 2020. JP Medical Ltd. ISBN 9781909836761

    Age-related macular degeneration
  • Juan L. Ang, Sarah Ah-Moye, Leah Kim, Vuong Nguyen, Adrian Hunt, Daniel Barthelmes, Mark C. Gillies, Hemal Mehta. A systematic review of real-world evidence of the management of macular oedema secondary to branch retinal vein occlusion. Eye (Lond). 2020 Apr 20. DOI:10.1038/s41433-020-0861-9.

    Retinal vein occlusion
  • Hemal Mehta, Leah N Kim, Thibaud Mathis, Pardis Zalmay, Faruque Ghanchi, Winfried M Amoaku, Laurent Kodjikian. Trends in real-world neovascular AMD treatment outcomes in the UK. Clinical Ophthalmology. 2020: 14 3331–3342. DOI:10.2147/OPTH.S275977.

    Age-related macular degeneration
  • Pierre-Henry Gabrielle, Vuong Nguyen, Sanjeeb Bhandari, Hemal Mehta, Francesco Viola, Jennifer Arnold, Samantha Fraser-Bell, Daniel Barthelmes, Catherine Creuzot-Garcher, Mark C. Gillies. Initial observation or treatment for diabetic macular oedema with good visual acuity: two-year outcomes comparison in routine clinical practice: data from the Fight Retinal Blindness! Registry. Acta Ophthalmol. 2020 Nov 16. In press. DOI: 10.1111/aos.14672.

    Diabetic retinopathy
  • K Mccafferty, B Caplin, S Knight, P Hockings, D Wheeler, SL Fan, J Hulthe, R Kleta, N Ashman, V Papastefanou, H Mehta, A Salama, S Hadzovic, TA Chowdhury, L Jarl, R Unwin, B Challis, AK Sundgren, MM Yaqoob. HEROIC: a 5-year observational cohort study aimed at identifying novel factors that drive diabetic kidney disease: rationale and study protocol. BMJ Open. 2020 Sep 9;10(9):e033923. DOI:0.1136/bmjopen-2019-033923.

    Retinal imaging
  • Winfried M. Amoaku, Faruque Ghanchi, Clare Bailey, Sanjiv Banerjee, Somnath Banerjee, Louise Downey, Richard Gale, Robin Hamilton, Kamlesh Khunti, Esther Posner, Fahd Quhill, Stephen Robinson, Roopa Setty, Dawn Sim, Deepali Varma, Hemal Mehta. Diabetic retinopathy and diabetic macular oedema pathways and management: UK Consensus Working Group. Eye (Lond.) Jun 20. 34:1–51 DOI.org/10.1038/s41433-020-0961-6.

    Diabetic retinopathy
  • Anne C. Biechl, Sanjeeb S. Bhandari, Vuong Nguyen, Jenny J. Arnold, Stephanie Young, Samantha Fraser-Bell, Hemal Mehta, Mark C. Gillies, Daniel Barthelmes. Changes in real-world treatment patterns for diabetic macular oedema from 2009-2019 and five-year outcomes: Data from the Fight Retinal Blindness! Registry. Clin Exp Ophthalmol. 2020 May 8. DOI: 10.1111/ceo.13781.

    Diabetic retinopathy
  • Adam H. Ross, Louise Downey, Helen Devonport, Richard P. Gale, Ajay Kotagiri, Sajjad Mahmood, Hemal Mehta, Niro Narendran, Praveen J. Patel, Nina Parmar, Nitin Jain. Recommendations by an expert panel on an aflibercept treat-and-extend pathway for the treatment of neovascular age-related macular degeneration. Eye (Lond). 2020 Jan 3. DOI:10.1038/s41433-019-0747.

    Age-related macular degeneration
  • Winfried M. Amoaku, Faruque Ghanchi, Clare Bailey, Sanjiv Banerjee, Somnath Banerjee, Louise Downey, Richard Gale, Robin Hamilton, Kamlesh Khunti, Esther Posner, Fahd Quhill, Stephen Robinson, Roopa Setty, Dawn Sim, Deepali Varma, Hemal Mehta. Diabetic retinopathy and diabetic macular oedema pathways and management: UK Consensus Working Group. Eye (Lond.) Jun 20. 34:1–51 DOI.org/10.1038/s41433-020-0961-6.

    Diabetic retinopathy
  • Sanjeeb Bhandari, Anne C. Biechl, Vuong Nguyen, David Squirrell, Hemal Mehta, Daniel Barthelmes, Mark C. Gillies. Outcomes of cataract surgery in eyes with diabetic macular oedema: Data from the Fight Retinal Blindness! Registry. Clin Exp Ophthalmol. 2019 Dec 29. DOI: 10.1111/ceo.13707.

    Cataract surgery
  • Sanjeeb Bhandari, Vuong Nguyen, Samantha Fraser-Bell, Hemal Mehta, Francesco Viola, Florian Baudin, Pierre H. Gabrielle, Catherine Creuzot-Garcher, Mark C. Gillies, Daniel Barthelmes. Ranibizumab or Aflibercept for Diabetic Macular Edema: Comparison of 1-Year Outcomes from the Fight Retinal Blindness! Registry. Ophthalmology. 2019 Nov 26. pii: S0161-6420(19)32299-7. doi: 10.1016/j.ophtha.2019.11.018.

    Diabetic retinopathy
  • Aaron W Joe, Sanj S. Wickremasinghe, Mark C. Gillies, Vuong Nguyen, Lyndell L Lim, Hemal Mehta, Samantha Fraser-Bell. Dexamethasone implant for the treatment of persistent diabetic macular oedema despite long-term treatment with bevacizumab. Clin Exp Ophthalmol. 2019 Mar;47(2):287-289. DOI: 10.1111/ceo.13371.

    Diabetic retinopathy
  • Hemal Mehta, Lyndell Lim, Vuong Nguyen, Dania Qatarneh, Sanjeev S. Wickremasinghe, Laura A. Hodgson, Godfrey J. Quin, Ian L. McAllister, Mark C. Gillies, Samantha Fraser-Bell. Development of new proliferative diabetic retinopathy in the BEVORDEX trial, Ophthalmology Retina, 2019 Mar;3(3):286-287. doi: 10.1016/j.oret.2018.10.010.

    Diabetic retinopathy
  • Siva Balasubramanian, Joanne Beckmann, Hemal Mehta, SriniVas R. Sadda, Karntida Chanwimol, Marco Nassisi, Irena Tsui, Neil Marlow, Saurabh Jain. Relationship between retinal thickness profiles and visual outcomes in young adults born extremely preterm: The EPICure@19 Study. Ophthalmology, 2019 Jan;126(1):107-112. DOI: 10.1016/j.ophtha.2018.07.030.

    Retinal imaging
  • Winfried Amoaku, Konstantinos Balaskas, Tomas Cudrnak, Louise Downey, Markus Groppe, Sajjad Mahmood, Hemal Mehta, Quresh Mohamed, Bushra Mushtaq, Philip Severn, Athanasios Vardarinos, Yit Yang, Saad Younis. Initiation and maintenance of a Treat-and-Extend regimen for ranibizumab therapy in wet age-related macular degeneration: recommendations from the Retinal Outcomes Group. Clinical Ophthalmology 2018:12 1731–1740. DOI: 10.2147/OPTH.S174560.

    Age-related macular degeneration
  • Charles Hennings, Jennifer Evans, Hemal Mehta. Letter to the Editor: Efficacy of the Intravitreal Sustained-Release Dexamethasone Implant for DME Refractory to Anti-VEGF Therapy: Meta-Analysis and Clinical Implications. Ophthalmic Surg Lasers Imaging Retina. 2018 Sep 1;49(9):654-655. DOI: 10.3928/23258160-20180831-01.

    Diabetic retinopathy
  • Hemal Mehta, Samantha Fraser-Bell, Vuong Nguyen, Lyndell L. Lim, Mark C. Gillies. Short-term vision gains at 12 weeks correlate with long-term vision gains at 2 years: results from the BEVORDEX randomised clinical trial of bevacizumab versus dexamethasone implants for diabetic macular oedema. British Journal of Ophthalmology, 04/2018. DOI: 10.1136/bjophthalmol-2017-310737.

    Diabetic retinopathy
  • Hemal Mehta, Samantha Fraser-Bell, Vuong Nguyen, Lyndell L. Lim, Mark C. Gillies. The Interval between Treatments of Bevacizumab and Dexamethasone Implants for Diabetic Macular Edema Increased over Time in the BEVORDEX Trial. Ophthalmology Retina, 03/2018. DOI: 10.1016/j.oret.2017.06.010.

    Diabetic retinopathy
  • Hemal Mehta, Charles Hennings, Mark C. Gillies, Vuong Nguyen, Anna Campain, Samantha Fraser-Bell. Anti-vascular endothelial growth factor combined with intravitreal steroids for diabetic macular oedema (Review). Cochrane Database of Systematic Reviews 2018, Issue 4. DOI: 10.1002/14651858.CD011599.pub2.

    Diabetic retinopathy
  • Hemal Mehta, Adnan Tufail, Vincent Daien, Aaron Lee, Vuong Nguyen, Mehmet Ozturk, Daniel Barthelmes, Mark C. Gillies. Real-world outcomes in patients with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth factor inhibitors. Progress in Retinal and Eye Research. Volume 65, July 2018, Pages 127-146. DOI: 10.1016/j.preteyeres.2017.12.002.

    Age-related macular degeneration
  • Mehmet Ozturk, Martin L. Harris, Vuong Nguyen, Daniel Barthelmes, Mark C. Gillies, Hemal Mehta. Real-world visual outcomes in patients with neovascular age-related macular degeneration receiving aflibercept at fixed intervals. (Fight Retinal Blindness Registry) Clinical and Experimental Ophthalmology, 10/2017 DOI: 10.1111/ceo.13085.

    Age-related macular degeneration
  • Sanjeev S. Wickremasinghe, Samantha Fraser-Bell, Elizabeth Alessandrello, Hemal Mehta, Mark C Gillies, Lyndell L Lim. Retinal vascular calibre changes after intravitreal bevacizumab or dexamethasone implant treatment for diabetic macular oedema. British Journal of Ophthalmology 10/2017; DOI: 10.1136/bjophthalmol-2016-309882.

    Retinal imaging
  • Yit Yang, Louise Downey, Hemal Mehta, Bushra Mushtaq, Niro Narendran, Nishal Patel, Praveen J Patel, Filis Ayan, Kara Gibson, Franklin Igwe, Pete Jeffery. Resource Use and Real-World Outcomes for Ranibizumab Treat and Extend for Neovascular Age-Related Macular Degeneration in the UK: Interim Results from TERRA. Ophthalmol Ther 06/2017; DOI: 10.1007/s40123-017-0091-9.

    Age-related macular degeneration
  • Leah N Kim, Hemal Mehta, Daniel Barthelmes, Vuong Nguyen, Mark C Gillies. Meta-analysis of real-world outcomes of intravitreal ranibizumab for the treatment of neovascular age-related macular degeneration. Retina 07/2016. DOI: 10.1097/IAE.0000000000001142.

    Age-related macular degeneration
  • Mohamed Katta, Hemal Mehta, Ivan Ho, Ray Garrick, Robert Chong. Optical coherence tomography imaging of optic disc cavernous haemangioma. J Clinical Neuroscience 07/2016. DOI: 10.1016/j.jocn.2016.04.010.

    Lesions at the back of the eye
  • Hemal Mehta, Simone Muller, Catherine A Egan, Adnan Tufail, Simona Degli Esposti, Adnan Tufail, Dawn A Sim, Frank G Holz, Winfried M Amoaku, Peter Charbel Issa, Mark C Gillies. Natural history and effect of therapeutic interventions on subretinal fluid causing foveal detachment in macular telangiectasia type 2. British Journal of Ophthalmology 07/2017; DOI: 10.1136/bjophthalmol-2016-309237.

    Macular telangiectasia
  • Hemal Mehta, Mark C Gillies, Samantha Fraser-Bell: Combination of vascular endothelial growth factor inhibitors and laser therapy for diabetic macula oedema: a review. Clinical and Experimental Ophthalmology 04/2016; DOI:10.1111/ceo.12757.

    Diabetic retinopathy
  • Kaivon Pakzad-Vaezi, Hemal Mehta, Zaid Mammo, Adnan Tufail: Vascular endothelial growth factor inhibitor use and treatment approach for choroidal neovascularization secondary to pathologic myopia. Expert opinion on biological therapy 03/2016; DOI:10.1517/14712598.2016.1167868.

    Pathological myopia
  • Samantha Fraser-Bell, Lyndell L Lim, Anna Campain, Hemal Mehta, Christine Aroney, Jaclyn Bryant, Ji Li, Godfrey J Quin, Ian L McAllister, Mark C Gillies: Bevacizumab or Dexamethasone Implants for DME: 2-year Results (The BEVORDEX Study). Ophthalmology 01/2016; DOI: 10.1016/j.ophtha.2015.12.012.

    Diabetic retinopathy
  • Hemal Mehta, Mark C Gillies, Samantha Fraser-Bell: Perspective on the role of Ozurdex (dexamethasone intravitreal implant) in the management of diabetic macular oedema. Therapeutic Advances in Chronic Disease 08/2015; 6(5):234-245. DOI:10.1177/2040622315590319.

    Diabetic retinopathy
  • Mark C Gillies, Hemal Mehta, Alan C Bird: Macular Telangiectasia Type 2 Without Clinically Detectable Vasculopathy. JAMA Ophthalmology 06/2015. DOI:10.1001/jamaophthalmol.2015.1796.

    Macular telangiectasia
  • Hemal Mehta, Dawn A Sim, Pearse A Keane, Javier Zarranz-Ventura, Kevin Gallagher, Catherine A Egan, Mark Westcott, Richard W J Lee, Adnan Tufail, Carlos E Pavesio: Structural changes of the choroid in sarcoid- and tuberculosis-related granulomatous uveitis. Eye (London, England) 05/2015; 29(8). DOI:10.1038/eye.2015.65.

    Lesions at the back of the eye
  • Hemal Mehta, Samantha Fraser-Bell, Aaron Yeung, Anna Campain, Lyndell L Lim, Godfrey J Quin, Ian L McAllister, Pearse A Keane, Mark C Gillies: Efficacy of dexamethasone versus bevacizumab on regression of hard exudates in diabetic maculopathy: data from the BEVORDEX randomised clinical trial. The British Journal of Ophthalmology 11/2015. DOI: 10.1136/bjophthalmol-2015-307797.

    Diabetic retinopathy
  • Cecilia S Lee, Aaron Y Lee, Dawn A Sim, Pearse A Keane, Hemal Mehta, Javier Zarranz-Ventura, Marcus Fruttiger, Catherine A Egan, Adnan Tufail: Reevaluating the Definition of Intraretinal Microvascular Abnormalities and Neovascularization Elsewhere in Diabetic Retinopathy Using Optical Coherence Tomography and Fluorescein Angiography. American Journal of Ophthalmology 10/2014; 159(1). DOI:10.1016/j.ajo.2014.09.041.

    Retinal imaging
  • Dawn A Sim, Pearse A Keane, Hemal Mehta, Simon Fung, Javier Zarranz-Ventura, Marcus Fruttiger, Praveen J Patel, Catherine A Egan, Adnan Tufail: Repeatability and Reproducibility of Choroidal Vessel Layer Measurements in Diabetic Retinopathy Using Enhanced Depth Optical Coherence Tomography. Investigative ophthalmology & visual science 03/2013; 54(4). DOI:10.1167/iovs.12-11085.

    Retinal imaging
  • Mandeep S Sagoo, Hemal Mehta, Andrew J Swampillai, Victoria M L Cohen, Sepideh Z Amin, P Nicholas Plowman, Sue Lightman: Primary Intraocular Lymphoma. Survey of Ophthalmology 01/2013; 59(5). DOI:10.1016/j.survophthal.2013.12.001.

    Lesions at the back of the eye
  • Dania Qatarneh, Hemal Mehta, Vickie Lee: Insight into Leber congenital amaurosis: Potential for gene therapy. Expert Review of Ophthalmology 03/2011; 6(2):203-209. DOI:10.1586/eop.11.7.

    Inherited retinal disease
  • Hemal Mehta, John L Hungerford, David S Gartry, Helen M Herbert, Prithvi Mruthyunjaya: Transpositional Autokeratoplasty in a Patient with Unilateral Choroidal Melanoma and Contralateral Exposure Keratopathy. Ophthalmic Surgery Lasers and Imaging 03/2010; DOI: 10.3928/15428877-20100215-41.

    Lesions at the back of the eye

Dr Hemal Mehta

MBBS MD(Cantab.) FRCOphth FRANZCO

Appointments:
TUESDAYS, FRIDAYS, SATURDAYS

Bondi Junction Retina Associates
Eastern Suburbs Eye Specialists

Appointments:
THURSDAYS

Appointments:
MONDAYS, TUESDAYS

Campbelltown Retina Associates
Macarthur Eye Specialists

Appointments:
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